Improvement of the female mouse computational model developed at CDTN

Small animals, such as mice, have been used in experiments involving ionizing radiation. New preclinical experimental methods often include extensive imaging (MicroCT and/or PET/SPECT) that can result absorbed dose values considerably high. In addition, assays with theranosticsradiopharmaceuticals administered small animals to determine the main potential adverse effects and therapeutic efficacy. For all these mentioned cases, precise quantification of doses determination energy deposition patterns are fundamental importance qualify or exclude radiobiological may interfere vivo experiment results. Thus, development improvement mouse phantoms is essential for good animal dosimetry. 2021, our group segmented implemented a female C57BL phantom, called FM_BRA, MCNP. The objective this work was review segmentation FM_BRA computational model identify segment new organs an improved version phantom. Three different researchers model. masses were compared those first version. Information on mass volume from strains, more specifically strain, also obtained literature comparison aid segmentation. mice image representing strain weighing 26 g kindly provided by Turku Center Disease manually segmented. software GIMP® 2.10 select each organ/tissue. IMAIOS-VET Anatomy website anatomical basis identification organs/tissues. IMAGEJ® applied assemble images into 3D stack convert binary files. volumes measured C++ house program. Corresponding human tissue densities ICRP 110 calculate organ calculated volumes. Data reports. number increased 20 old 33 models. work, researchers, showed agreement most cases. However, intestines, bones trachea still deserve round reviewing.